Phosphodiesterase 4 inhibitors enhance sexual pleasure-seeking activity in rodents

Pleasure-seeking deficits, including lack of libido, are a core feature of depression. Animal and preliminary clinical studies both suggest that phosphodiesterase 4 (PDE4) is a target for developing novel antidepressants. This study examined the potential involvement of PDE4 in the pathology of depr...

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Main Authors: Yuan, Peixiong, Tragon, Tyson, Xia, Menghang, LeClair, Christopher A., Skoumbourdis, Amanda P., Zheng, Wei, Thomas, Craig J., Huang, Ruili, Austin, Christopher P., Chen, Guang, Guitart, Xavier
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065502/
https://ncbi.nlm.nih.gov/pubmed/21296104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbb.2011.02.001
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