Exploration and Optimization of Substituted Triazolothiadiazines and Triazolopyridazines as PDE4 Inhibitors

An expansion of structure-activity studies on a series of substituted 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine PDE4 inhibitors and the introduction of a related [1,2,4]triazolo[4,3-b]pyridazine based inhibitor of PDE4 is presented. The development of SAR included strategic incorporation of known...

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Hlavní autoři: Skoumbourdis, Amanda P., LeClair, Christopher A., Stefan, Eduard, Turjanski, Adrian G., Maguire, William, Titus, Steven A., Huang, Ruili, Auld, Douglas S., Inglese, James, Austin, Christopher P., Michnick, Stephen W., Xia, Menghang, Thomas, Craig J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2870997/
https://ncbi.nlm.nih.gov/pubmed/19464886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.01.057
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