A 7-phenyl substituted triazolopyridazine has inverse agonist activity at the benzodiazepine receptor site.

To investigate further the structural requirements for benzodiazepine (BZD) receptor ligands, we synthesized SR 95195, [7-phenyl-3-methyl-1,2,4-triazolo-(4,3-b) pyridazine], a positional isomer of the 6-phenyl-triazolo-pyridazines, which were the first non-BZD derivatives to exhibit high affinity fo...

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Bibliographic Details
Main Authors: Biziere, K., Bourguignon, J. J., Chambon, J. P., Heaulme, M., Perio, A., Tebib, S., Wermuth, C. G.
Format: Artigo
Language:Inglês
Published: 1987
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1917288/
https://ncbi.nlm.nih.gov/pubmed/3028557
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