An arylaminopyridazine derivative of gamma-aminobutyric acid (GABA) is a selective and competitive antagonist at the GABAA receptor site.

In view of finding a new gamma-aminobutyric acid (GABA) receptor ligand we synthesized an arylaminopyridazine derivative of GABA, SR 95103 [2-(carboxy-3'-propyl)-3-amino-4-methyl-6-phenylpyridazinium chloride]. SR 95103 displaced [3H]GABA from rat brain membranes with an apparent Ki of 2.2 micr...

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Detalhes bibliográficos
Main Authors: Chambon, J P, Feltz, P, Heaulme, M, Restle, S, Schlichter, R, Biziere, K, Wermuth, C G
Formato: Artigo
Idioma:Inglês
Publicado em: 1985
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC397367/
https://ncbi.nlm.nih.gov/pubmed/2984669
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