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An arylaminopyridazine derivative of gamma-aminobutyric acid (GABA) is a selective and competitive antagonist at the GABAA receptor site.

In view of finding a new gamma-aminobutyric acid (GABA) receptor ligand we synthesized an arylaminopyridazine derivative of GABA, SR 95103 [2-(carboxy-3'-propyl)-3-amino-4-methyl-6-phenylpyridazinium chloride]. SR 95103 displaced [3H]GABA from rat brain membranes with an apparent Ki of 2.2 microM an...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Chambon, J P, Feltz, P, Heaulme, M, Restle, S, Schlichter, R, Biziere, K, Wermuth, C G
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1985
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397367/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2984669/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.6.1832
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