An arylaminopyridazine derivative of gamma-aminobutyric acid (GABA) is a selective and competitive antagonist at the GABAA receptor site.

In view of finding a new gamma-aminobutyric acid (GABA) receptor ligand we synthesized an arylaminopyridazine derivative of GABA, SR 95103 [2-(carboxy-3'-propyl)-3-amino-4-methyl-6-phenylpyridazinium chloride]. SR 95103 displaced [3H]GABA from rat brain membranes with an apparent Ki of 2.2 microM an...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Chambon, J P, Feltz, P, Heaulme, M, Restle, S, Schlichter, R, Biziere, K, Wermuth, C G
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1985
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397367/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2984669/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.6.1832
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