Ethynyl and Propynylpyrene Inhibitors of Cytochrome P450

The single-crystal X-ray structures and in vivo activities of three aryl acetylenic inhibitors of cytochromes P450 1A1, 1A2, 2A6, and 2B1 have been determined and are reported herein. These are 1-ethynylpyrene, 1-propy-nylpyrene, and 4-propynylpyrene. To investigate electronic influences on the mech...

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Bibliographic Details
Main Authors: Zhu, Naijue, Lightsey, Danielle, Liu, Jiawang, Foroozesh, Maryam, Morgan, Kathleen M., Stevens, Edwin D., Klein Stevens, Cheryl L.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2869100/
https://ncbi.nlm.nih.gov/pubmed/20473363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10870-009-9659-0
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