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Ethynyl and Propynylpyrene Inhibitors of Cytochrome P450
The single-crystal X-ray structures and in vivo activities of three aryl acetylenic inhibitors of cytochromes P450 1A1, 1A2, 2A6, and 2B1 have been determined and are reported herein. These are 1-ethynylpyrene, 1-propy-nylpyrene, and 4-propynylpyrene. To investigate electronic influences on the mech...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2869100/ https://ncbi.nlm.nih.gov/pubmed/20473363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10870-009-9659-0 |
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