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ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation

ErbB3/HER3 is one of four members of the human epidermal growth factor receptor (EGFR/HER) or ErbB receptor tyrosine kinase family. ErbB3 binds neuregulins via its extracellular region and signals primarily by heterodimerizing with ErbB2/HER2/Neu. A recently appreciated role for ErbB3 in resistance...

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Main Authors: Shi, Fumin, Telesco, Shannon E., Liu, Yingting, Radhakrishnan, Ravi, Lemmon, Mark A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867849/
https://ncbi.nlm.nih.gov/pubmed/20351256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002753107
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