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Glucose downregulation of PKG-I protein mediates increased thrombospondin1-dependent TGF-β activity in vascular smooth muscle cells

Diabetes is a major predictor of in-stent restenosis, which is associated with fibroproliferative remodeling of the vascular wall due to increased transforming growth factor-β (TGF-β) action. It is well established that thrombospondin1 (TSP1) is a major regulator of TGF-β activation in renal and car...

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Detalhes bibliográficos
Main Authors: Wang, Shuxia, Lincoln, Thomas M., Murphy-Ullrich, Joanne E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867397/
https://ncbi.nlm.nih.gov/pubmed/20164378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00330.2009
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