MyD88-dependent TLR4 signaling is selectively impaired in alveolar macrophages from asymptomatic HIV(+) persons

Alveolar macrophages (AMs) are the predominant effector cell in the lungs and contribute to a critical first line of defense against bacterial pathogens through recognition by pattern recognition receptors such as Toll-like receptor 4 (TLR4). TLR4-mediated tumor necrosis factor α (TNFα) release is s...

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Detalhes bibliográficos
Principais autores: Tachado, Souvenir D., Li, Xin, Bole, Medhavi, Swan, Katharine, Anandaiah, Asha, Patel, Naimish R., Koziel, Henry
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Phagocytes, Granulocytes, and Myelopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867269/
https://ncbi.nlm.nih.gov/pubmed/20197549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-10-250787
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