mTOR inhibition in macrophages of asymptomatic HIV+ persons reverses the decrease in TLR4-mediated TNFα release through prolongation of MAPK pathway activation

Toll-like receptor 4 (TLR4) mediated signaling is significantly impaired in macrophages from HIV+ persons predominantly due to altered MyD88-dependent pathway signaling caused in part by constitutive activation of PI3K. Here we assessed in these macrophages if the blunted increase in TLR4-mediated T...

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Hlavní autoři: Li, Xin, Han, Xinbing, Llano, Juliana, Bole, Medhavi, Zhou, Xiuqin, Swan, Katharine, Anandaiah, Asha, Nelson, Benjamin, Patel, Naimish R., Reinach, Peter S., Koziel, Henry, Tachado, Souvenir D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221743/
https://ncbi.nlm.nih.gov/pubmed/22025552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1101532
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