Constitutive Activation of Phosphatidylinositol 3-Kinase Signaling Pathway Down-regulates TLR4-mediated Tumor Necrosis Factor-α Release in Alveolar Macrophages from Asymptomatic HIV-positive Persons in Vitro

Alveolar macrophages represent critical effector cells of innate immunity to infectious challenge in the lungs and recognize bacterial pathogens through pattern recognition receptors such as Toll-like receptors (TLRs). Phosphatidylinositol 3-kinse (PI3K) regulates TLR-mediated cytokine release, but...

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Detalhes bibliográficos
Main Authors: Tachado, Souvenir D., Li, Xin, Swan, Katharine, Patel, Naimish, Koziel, Henry
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586243/
https://ncbi.nlm.nih.gov/pubmed/18826950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805067200
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