Epigenetic Regulation of Tumor Necrosis Factor α (TNFα) Release in Human Macrophages by HIV-1 Single-stranded RNA (ssRNA) Is Dependent on TLR8 Signaling

Human macrophages at mucosal sites are essential targets for acute HIV infection. During the chronic phase of infection, they are persistent reservoirs for the AIDS virus. HIV virions gain entry into macrophages following ligation of surface CD4-CCR5 co-receptors, which leads to the release of two c...

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Detalhes bibliográficos
Main Authors: Han, Xinbing, Li, Xin, Yue, Simon C., Anandaiah, Asha, Hashem, Falah, Reinach, Peter S., Koziel, Henry, Tachado, Souvenir D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340209/
https://ncbi.nlm.nih.gov/pubmed/22393042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.342683
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