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Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage

Fanconi anemia (FA) is a genetically heterogeneous, autosomal recessive disorder characterized by pediatric bone marrow failure and congenital anomalies. The effect of FA gene deficiency on hematopoietic development in utero remains poorly described as mouse models of FA do not develop hematopoietic...

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Hlavní autoři: Tulpule, Asmin, Lensch, M. William, Miller, Justine D., Austin, Karyn, D'Andrea, Alan, Schlaeger, Thorsten M., Shimamura, Akiko, Daley, George Q.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867260/
https://ncbi.nlm.nih.gov/pubmed/20089964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-10-246694
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