An induced pluripotent stem cell model of Fanconi anemia reveals mechanisms of p53-driven progenitor cell differentiation

Fanconi anemia (FA) is a disorder of DNA repair that manifests as bone marrow (BM) failure. The lack of accurate murine models of FA has refocused efforts toward differentiation of patient-derived induced pluripotent stem cells (IPSCs) to hematopoietic progenitor cells (HPCs). However, an intact FA...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Marion, William, Boettcher, Steffen, Ruiz-Torres, Sonya, Lummertz da Rocha, Edroaldo, Lundin, Vanessa, Morris, Vivian, Chou, Stephanie, Zhao, Anna M., Kubaczka, Caroline, Aumais, Olivia, Zhang, Yosra, Shimamura, Akiko, Schlaeger, Thorsten M., North, Trista E., Ebert, Benjamin L., Wells, Susanne I., Daley, George Q., Rowe, R. Grant
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556119/
https://ncbi.nlm.nih.gov/pubmed/33002135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001593
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