An induced pluripotent stem cell model of Fanconi anemia reveals mechanisms of p53-driven progenitor cell differentiation

Fanconi anemia (FA) is a disorder of DNA repair that manifests as bone marrow (BM) failure. The lack of accurate murine models of FA has refocused efforts toward differentiation of patient-derived induced pluripotent stem cells (IPSCs) to hematopoietic progenitor cells (HPCs). However, an intact FA...

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Bibliografische gegevens
Gepubliceerd in:Blood Adv
Hoofdauteurs: Marion, William, Boettcher, Steffen, Ruiz-Torres, Sonya, Lummertz da Rocha, Edroaldo, Lundin, Vanessa, Morris, Vivian, Chou, Stephanie, Zhao, Anna M., Kubaczka, Caroline, Aumais, Olivia, Zhang, Yosra, Shimamura, Akiko, Schlaeger, Thorsten M., North, Trista E., Ebert, Benjamin L., Wells, Susanne I., Daley, George Q., Rowe, R. Grant
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2020
Onderwerpen:
Hematopoiesis and Stem Cells
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556119/
https://ncbi.nlm.nih.gov/pubmed/33002135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001593
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