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Amyloidogenic sequences in native protein structures

Numerous short peptides have been shown to form β-sheet amyloid aggregates in vitro. Proteins that contain such sequences are likely to be problematic for a cell, due to their potential to aggregate into toxic structures. We investigated the structures of 30 proteins containing 45 sequences known to...

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Detalhes bibliográficos
Main Authors: Tzotzos, Susan, Doig, Andrew J
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865711/
https://ncbi.nlm.nih.gov/pubmed/20027621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.314
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