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The preaggregated state of an amyloidogenic protein: Hydrostatic pressure converts native transthyretin into the amyloidogenic state

Protein misfolding and aggregation cause several diseases, by mechanisms that are poorly understood. The formation of amyloid aggregates is the hallmark of most of these diseases. Here, the properties and formation of amyloidogenic intermediates of transthyretin (TTR) were investigated by the use of...

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Auteurs principaux: Ferrão-Gonzales, Astria D., Souto, Sandro O., Silva, Jerson L., Foguel, Débora
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2000
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC18622/
https://ncbi.nlm.nih.gov/pubmed/10841549
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