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Designing transthyretin mutants affecting tetrameric structure: implications in amyloidogenicity.

The molecular mechanisms that convert soluble transthyretin (TTR) tetramers into insoluble amyloid fibrils are still unknown; dissociation of the TTR tetramer is a pre-requisite for amyloid formation in vitro and involvement of monomers and/or dimers in fibril formation has been suggested by structu...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Redondo, C, Damas, A M, Saraiva, M J
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2000
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1221050/
https://ncbi.nlm.nih.gov/pubmed/10794728
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