Potent and Selective Fluoroketone Inhibitors of Group VIA Calcium-Independent Phospholipase A(2)

Group VIA calcium-independent phospholipase A(2) (GVIA iPLA(2)) has recently emerged as a novel pharmaceutical target. We have now explored the structure-activity relationship between fluoroketones and GVIA iPLA(2) inhibition. The presence of a naphthyl group proved to be of paramount importance. 1,...

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Main Authors: Kokotos, George, Hsu, Yuan-Hao, Burke, John E., Baskakis, Constantinos, Kokotos, Christoforos G., Magrioti, Victoria, Dennis, Edward A.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865582/
https://ncbi.nlm.nih.gov/pubmed/20369880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901872v
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