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Aberrant Methylation of Multiple Tumor Suppressor Genes in Aging Liver, Chronic Hepatitis, and Hepatocellular Carcinoma

Aberrant DNA methylation is an important epigenetic alteration in hepatocellular carcinoma (HCC). However, the molecular processes underlying the methylator phenotype and the contribution of hepatitis viruses are poorly understood. The current study is a comprehensive methylation analysis of human l...

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Detalhes bibliográficos
Main Authors: Nishida, Naoshi, Nagasaka, Takeshi, Nishimura, Takafumi, Ikai, Iwao, Boland, C. Richard, Goel, Ajay
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865182/
https://ncbi.nlm.nih.gov/pubmed/18161048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.22110
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