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Determinants for phosphodiesterase-6 inhibition by its γ-subunit

The interaction of phosphodiesterase 6 (PDE6) with its inhibitory Pγ-subunits is unparalleled among PDE families and is central for vertebrate phototransduction. The C-terminus of Pγ occludes the active site of PDE6 thereby preventing hydrolysis of cGMP. In this study we examined the determinants of...

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Bibliografiska uppgifter
Huvudupphovsmän: Zhang, Zhongming, Artemyev, Nikolai O.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864356/
https://ncbi.nlm.nih.gov/pubmed/20397626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100354a
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