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Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the γ-subunit
The inhibitory interaction of phosphodiesterase-6 (PDE6) with its γ-subunit (Pγ) is pivotal in vertebrate phototransduction. Here, crystal structures of a chimaeric PDE5/PDE6 catalytic domain (PDE5/6cd) complexed with sildenafil or 3-isobutyl-1-methylxanthine and the Pγ-inhibitory peptide Pγ(70−87)...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2782096/ https://ncbi.nlm.nih.gov/pubmed/19798052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.284 |
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