Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the γ-subunit

The inhibitory interaction of phosphodiesterase-6 (PDE6) with its γ-subunit (Pγ) is pivotal in vertebrate phototransduction. Here, crystal structures of a chimaeric PDE5/PDE6 catalytic domain (PDE5/6cd) complexed with sildenafil or 3-isobutyl-1-methylxanthine and the Pγ-inhibitory peptide Pγ(70−87)...

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Detalhes bibliográficos
Main Authors: Barren, Brandy, Gakhar, Lokesh, Muradov, Hakim, Boyd, Kimberly K, Ramaswamy, S, Artemyev, Nikolai O
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782096/
https://ncbi.nlm.nih.gov/pubmed/19798052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.284
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