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Determinants for phosphodiesterase-6 inhibition by its γ-subunit
The interaction of phosphodiesterase 6 (PDE6) with its inhibitory Pγ-subunits is unparalleled among PDE families and is central for vertebrate phototransduction. The C-terminus of Pγ occludes the active site of PDE6 thereby preventing hydrolysis of cGMP. In this study we examined the determinants of...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2864356/ https://ncbi.nlm.nih.gov/pubmed/20397626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100354a |
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