Mouse Rad1 deletion enhances susceptibility for skin tumor development

BACKGROUND: Cells are constantly exposed to stresses from cellular metabolites as well as environmental genotoxins. DNA damage caused by these genotoxins can be efficiently fixed by DNA repair in cooperation with cell cycle checkpoints. Unrepaired DNA lesions can lead to cell death, gene mutation an...

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Autori principali: Han, Lu, Hu, Zhishang, Liu, Yuheng, Wang, Xiangyuan, Hopkins, Kevin M, Lieberman, Howard B, Hang, Haiying
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2010
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864214/
https://ncbi.nlm.nih.gov/pubmed/20334655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-67
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