NAD(+) Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death

Poly(ADP-ribose)-1 (PARP-1) is a key mediator of cell death in excitotoxicity, ischemia, and oxidative stress. PARP-1 activation leads to cytosolic NAD(+) depletion and mitochondrial release of apoptosis-inducing factor (AIF), but the causal relationships between these two events have been difficult...

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Main Authors: Alano, Conrad C., Garnier, Philippe, Ying, Weihai, Higashi, Youichirou, Kauppinen, Tiina M., Swanson, Raymond A.
格式: Artigo
語言:Inglês
出版: Society for Neuroscience 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864043/
https://ncbi.nlm.nih.gov/pubmed/20181594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5552-09.2010
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