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Poly(ADP-ribose) polymerase-1-induced NAD(+) depletion promotes nuclear factor-κB transcriptional activity by preventing p65 de-acetylation
NF-κB is a transcription factor that integrates pro-inflammatory and pro-survival responses in diverse cell types. The activity of NF-κB is regulated in part by acetylation of its p65 subunit at lysine 310,which is required for transcription complex formation. De-acetylation at this site is performe...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4041949/ https://ncbi.nlm.nih.gov/pubmed/23597856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2013.04.005 |
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