Generation of the Pathogenic R5-Tropic Simian/Human Immunodeficiency Virus SHIV(AD8) by Serial Passaging in Rhesus Macaques

A new pathogenic R5-tropic simian/human immunodeficiency virus (SHIV) was generated following serial passaging in rhesus macaques. All 13 animals inoculated with SHIV(AD8) passaged lineages experienced marked depletions of CD4(+) T cells. Ten of these infected monkeys became normal progressors (NPs)...

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Detalhes bibliográficos
Main Authors: Nishimura, Yoshiaki, Shingai, Masashi, Willey, Ronald, Sadjadpour, Reza, Lee, Wendy R., Brown, Charles R., Brenchley, Jason M., Buckler-White, Alicia, Petros, Rahel, Eckhaus, Michael, Hoffman, Victoria, Igarashi, Tatsuhiko, Martin, Malcolm A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863788/
https://ncbi.nlm.nih.gov/pubmed/20147396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02279-09
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