Most rhesus macaques infected with the CCR5-tropic SHIV(AD8) generate cross-reactive antibodies that neutralize multiple HIV-1 strains

The induction of broadly reacting neutralizing antibodies has been a major goal of HIV vaccine research. Characterization of a pathogenic CCR5 (R5)-tropic SIV/HIV chimeric virus (SHIV) molecular clone (SHIV(AD8-EO)) revealed that eight of eight infected animals developed cross-reactive neutralizing...

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Auteurs principaux: Shingai, Masashi, Donau, Olivia K., Schmidt, Stephen D., Gautam, Rajeev, Plishka, Ronald J., Buckler-White, Alicia, Sadjadpour, Reza, Lee, Wendy R., LaBranche, Celia C., Montefiori, David C., Mascola, John R., Nishimura, Yoshiaki, Martin, Malcolm A.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2012
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511737/
https://ncbi.nlm.nih.gov/pubmed/23129652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217443109
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