Pathogenicity and Mucosal Transmissibility of the R5-Tropic Simian/Human Immunodeficiency Virus SHIV(AD8) in Rhesus Macaques: Implications for Use in Vaccine Studies

There is an urgent need to develop new pathogenic R5 simian/human immunodeficiency viruses (SHIVs) for the evaluation of candidate anti-HIV vaccines in nonhuman primates. Here, we characterize swarm SHIV(AD8) stocks, prepared from three infected rhesus macaques with documented immunodeficiency at th...

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Autors principals: Gautam, Rajeev, Nishimura, Yoshiaki, Lee, Wendy R., Donau, Olivia, Buckler-White, Alicia, Shingai, Masashi, Sadjadpour, Reza, Schmidt, Stephen D., LaBranche, Celia C., Keele, Brandon F., Montefiori, David, Mascola, John R., Martin, Malcolm A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421705/
https://ncbi.nlm.nih.gov/pubmed/22647691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00644-12
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