Initiation of Antiretroviral Therapy 48 Hours after Infection with Simian Immunodeficiency Virus Potently Suppresses Acute-Phase Viremia and Blocks the Massive Loss of Memory CD4(+) T Cells but Fails To Prevent Disease

We investigated whether a 28-day course of potent antiretroviral therapy, initiated at a time point (48 h postinoculation) following simian immunodeficiency virus (SIV) inoculation when the acquisition of a viral infection was virtually assured, would sufficiently sensitize the immune system and res...

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Detalhes bibliográficos
Main Authors: Kubo, Makoto, Nishimura, Yoshiaki, Shingai, Masashi, Lee, Wendy, Brenchley, Jason, Lafont, Bernard, Buckler-White, Alicia, Igarashi, Tatsuhiko, Martin, Malcolm A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Cellular Response to Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704794/
https://ncbi.nlm.nih.gov/pubmed/19420078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02522-08
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