The Epstein-Barr Virus (EBV)-Encoded Protein Kinase, EBV-PK, but Not the Thymidine Kinase (EBV-TK), Is Required for Ganciclovir and Acyclovir Inhibition of Lytic Viral Production

Ganciclovir (GCV) and acyclovir (ACV) are guanine nucleoside analogues that inhibit lytic herpesvirus replication. GCV and ACV must be monophosphorylated by virally encoded enzymes to be converted into nucleotides and incorporated into viral DNA. However, whether GCV and/or ACV phosphorylation in Ep...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Meng, Qiao, Hagemeier, Stacy R., Fingeroth, Joyce D., Gershburg, Edward, Pagano, Joseph S., Kenney, Shannon C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology (ASM) 2010
Pynciau:
Genome Replication and Regulation of Viral Gene Expression
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863746/
https://ncbi.nlm.nih.gov/pubmed/20181711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02487-09
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