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PB1-F2 Expression by the 2009 Pandemic H1N1 Influenza Virus Has Minimal Impact on Virulence in Animal Models

Unlike previous pandemic viruses, the 2009 H1N1 pandemic influenza virus does not code for the virulence factor PB1-F2. The genome of the 2009 H1N1 virus contains three stop codons preventing PB1-F2 expression; however, PB1-F2 production could occur following genetic mutation or reassortment. Thus,...

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Detaylı Bibliyografya
Asıl Yazarlar: Hai, Rong, Schmolke, Mirco, Varga, Zsuzsanna T., Manicassamy, Balaji, Wang, Taia T., Belser, Jessica A., Pearce, Melissa B., García-Sastre, Adolfo, Tumpey, Terrence M., Palese, Peter
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology (ASM) 2010
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863736/
https://ncbi.nlm.nih.gov/pubmed/20181699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02717-09
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