A Single N66S Mutation in the PB1-F2 Protein of Influenza A Virus Increases Virulence by Inhibiting the Early Interferon Response In Vivo

The PB1-F2 protein of influenza A virus can contribute to viral pathogenesis of influenza virus strains. Of note, an N66S amino acid mutation in PB1-F2 has been shown to increase the pathogenesis associated with H5N1 Hong Kong/1997 and H1N1 Brevig Mission/1918 influenza viruses. To identify the mech...

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Hlavní autoři: Conenello, Gina M., Tisoncik, Jennifer R., Rosenzweig, Elizabeth, Varga, Zsuzsanna T., Palese, Peter, Katze, Michael G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2011
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020033/
https://ncbi.nlm.nih.gov/pubmed/21084483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01987-10
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