PB1-F2 Expression by the 2009 Pandemic H1N1 Influenza Virus Has Minimal Impact on Virulence in Animal Models

Unlike previous pandemic viruses, the 2009 H1N1 pandemic influenza virus does not code for the virulence factor PB1-F2. The genome of the 2009 H1N1 virus contains three stop codons preventing PB1-F2 expression; however, PB1-F2 production could occur following genetic mutation or reassortment. Thus,...

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Detalhes bibliográficos
Main Authors: Hai, Rong, Schmolke, Mirco, Varga, Zsuzsanna T., Manicassamy, Balaji, Wang, Taia T., Belser, Jessica A., Pearce, Melissa B., García-Sastre, Adolfo, Tumpey, Terrence M., Palese, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863736/
https://ncbi.nlm.nih.gov/pubmed/20181699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02717-09
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