PB1-F2 Expression by the 2009 Pandemic H1N1 Influenza Virus Has Minimal Impact on Virulence in Animal Models

Unlike previous pandemic viruses, the 2009 H1N1 pandemic influenza virus does not code for the virulence factor PB1-F2. The genome of the 2009 H1N1 virus contains three stop codons preventing PB1-F2 expression; however, PB1-F2 production could occur following genetic mutation or reassortment. Thus,...

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Hlavní autoři: Hai, Rong, Schmolke, Mirco, Varga, Zsuzsanna T., Manicassamy, Balaji, Wang, Taia T., Belser, Jessica A., Pearce, Melissa B., García-Sastre, Adolfo, Tumpey, Terrence M., Palese, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863736/
https://ncbi.nlm.nih.gov/pubmed/20181699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02717-09
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