Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virus

The 1918 influenza pandemic was exceptionally severe, resulting in the death of up to 50 million people worldwide. Here, we show which virus genes contributed to the replication and virulence of the 1918 influenza virus. Recombinant viruses, in which genes of the 1918 virus were replaced with genes...

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Autores principales: Pappas, Claudia, Aguilar, Patricia V., Basler, Christopher F., Solórzano, Alicia, Zeng, Hui, Perrone, Lucy A., Palese, Peter, García-Sastre, Adolfo, Katz, Jacqueline M., Tumpey, Terrence M.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2008
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268585/
https://ncbi.nlm.nih.gov/pubmed/18287069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711815105
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