Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virus

The 1918 influenza pandemic was exceptionally severe, resulting in the death of up to 50 million people worldwide. Here, we show which virus genes contributed to the replication and virulence of the 1918 influenza virus. Recombinant viruses, in which genes of the 1918 virus were replaced with genes...

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Main Authors: Pappas, Claudia, Aguilar, Patricia V., Basler, Christopher F., Solórzano, Alicia, Zeng, Hui, Perrone, Lucy A., Palese, Peter, García-Sastre, Adolfo, Katz, Jacqueline M., Tumpey, Terrence M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268585/
https://ncbi.nlm.nih.gov/pubmed/18287069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711815105
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