Differential Contribution of PB1-F2 to the Virulence of Highly Pathogenic H5N1 Influenza A Virus in Mammalian and Avian Species

Highly pathogenic avian influenza A viruses (HPAIV) of the H5N1 subtype occasionally transmit from birds to humans and can cause severe systemic infections in both hosts. PB1-F2 is an alternative translation product of the viral PB1 segment that was initially characterized as a pro-apoptotic mitocho...

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Main Authors: Schmolke, Mirco, Manicassamy, Balaji, Pena, Lindomar, Sutton, Troy, Hai, Rong, Varga, Zsuzsanna T., Hale, Benjamin G., Steel, John, Pérez, Daniel R., García-Sastre, Adolfo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154844/
https://ncbi.nlm.nih.gov/pubmed/21852950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002186
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