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Dynamic Effects of Cofactors and DNA on the Oligomeric State of Human Mitochondrial DNA Helicase

We examined the effects of cofactors and DNA on the stability, oligomeric state and conformation of the human mitochondrial DNA helicase. We demonstrate that low salt conditions result in protein aggregation that may cause dissociation of oligomeric structure. The low salt sensitivity of the mitocho...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ziebarth, Tawn D., Gonzalez-Soltero, Rocio, Makowska-Grzyska, Magdalena M., Núñez-Ramírez, Rafael, Carazo, Jose-Maria, Kaguni, Laurie S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863210/
https://ncbi.nlm.nih.gov/pubmed/20212038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.099663
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