Dynamic Effects of Cofactors and DNA on the Oligomeric State of Human Mitochondrial DNA Helicase

We examined the effects of cofactors and DNA on the stability, oligomeric state and conformation of the human mitochondrial DNA helicase. We demonstrate that low salt conditions result in protein aggregation that may cause dissociation of oligomeric structure. The low salt sensitivity of the mitocho...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Ziebarth, Tawn D., Gonzalez-Soltero, Rocio, Makowska-Grzyska, Magdalena M., Núñez-Ramírez, Rafael, Carazo, Jose-Maria, Kaguni, Laurie S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2010
Gaiak:
DNA and Chromosomes
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863210/
https://ncbi.nlm.nih.gov/pubmed/20212038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.099663
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