Sensitivity to Poly(ADP-ribose) Polymerase (PARP) Inhibition Identifies Ubiquitin-specific Peptidase 11 (USP11) as a Regulator of DNA Double-strand Break Repair

DNA damage repair and checkpoint responses prevent genome instability and provide a barrier to the development of cancer. Inherited mutations in DNA damage response (DDR) genes such as those that encode the homologous recombination (HR) proteins BRCA1 and BRCA2 cause cancer predisposition syndromes....

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Bibliografski detalji
Glavni autori: Wiltshire, Timothy D., Lovejoy, Courtney A., Wang, Tong, Xia, Fen, O'Connor, Mark J., Cortez, David
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
DNA and Chromosomes
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863164/
https://ncbi.nlm.nih.gov/pubmed/20233726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.104745
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