Sensitivity to Poly(ADP-ribose) Polymerase (PARP) Inhibition Identifies Ubiquitin-specific Peptidase 11 (USP11) as a Regulator of DNA Double-strand Break Repair

DNA damage repair and checkpoint responses prevent genome instability and provide a barrier to the development of cancer. Inherited mutations in DNA damage response (DDR) genes such as those that encode the homologous recombination (HR) proteins BRCA1 and BRCA2 cause cancer predisposition syndromes....

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Detalhes bibliográficos
Main Authors: Wiltshire, Timothy D., Lovejoy, Courtney A., Wang, Tong, Xia, Fen, O'Connor, Mark J., Cortez, David
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863164/
https://ncbi.nlm.nih.gov/pubmed/20233726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.104745
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