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The Palladium-Catalyzed Aerobic Kinetic Resolution of Secondary Alcohols: Reaction Development, Scope, and Applications

The first palladium-catalyzed enantioselective oxidation of secondary alcohols has been developed, utilizing the readily available diamine (−)-sparteine as chiral ligand and molecular oxygen as the stoichiometric oxidant. Mechanistic insights regarding the role of base and hydrogen bond donors have...

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Bibliografiske detaljer
Main Authors: Ebner, David C., Bagdanoff, Jeffrey T., Ferreira, Eric M., McFadden, Ryan M., Caspi, Daniel D., Trend, Raissa M., Stoltz, Brian M.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862982/
https://ncbi.nlm.nih.gov/pubmed/19904777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.200902172
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