Selective and potent furin inhibitors protect cells from anthrax without significant toxicity

Furin and related proprotein convertases cleave the multibasic motifs R-X-R/K/X-R in the precursor proteins and, as a result, transform the latent proproteins into biologically active proteins and peptides. Furin is present both in the intracellular secretory pathway and at the cell surface. Intrace...

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Detalles Bibliográficos
Autores principales: Remacle, Albert G., Gawlik, Katarzyna, Golubkov, Vladislav S., Cadwell, Gregory W., Liddington, Robert C., Cieplak, Piotr, Millis, Sherri Z., Desjardins, Roxane, Routhier, Sophie, Yuan, Xue Wen, Neugebauer, Witold A., Day, Robert, Strongin, Alex Y.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862824/
https://ncbi.nlm.nih.gov/pubmed/20197107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2010.02.013
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