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E3 Ligase Nedd4 Promotes Axon Branching by Downregulating PTEN

Regulated protein degradation via the ubiquitin-proteasome system (UPS) plays a central role in building synaptic connections, yet little is known about either which specific UPS components are involved or UPS targets in neurons. We report that inhibiting the UPS in developing Xenopus retinal gangli...

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Main Authors: Drinjakovic, Jovana, Jung, Hosung, Campbell, Douglas S., Strochlic, Laure, Dwivedy, Asha, Holt, Christine E.
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862300/
https://ncbi.nlm.nih.gov/pubmed/20159448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.01.017
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