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E3 Ligase Nedd4 Promotes Axon Branching by Downregulating PTEN

Regulated protein degradation via the ubiquitin-proteasome system (UPS) plays a central role in building synaptic connections, yet little is known about either which specific UPS components are involved or UPS targets in neurons. We report that inhibiting the UPS in developing Xenopus retinal gangli...

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Detalhes bibliográficos
Main Authors: Drinjakovic, Jovana, Jung, Hosung, Campbell, Douglas S., Strochlic, Laure, Dwivedy, Asha, Holt, Christine E.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862300/
https://ncbi.nlm.nih.gov/pubmed/20159448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.01.017
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