RNA Polymerase Activity and Specific RNA Structure Are Required for Efficient HCV Replication in Cultured Cells

We have previously reported that the NS3 helicase (N3H) and NS5B-to-3′X (N5BX) regions are important for the efficient replication of hepatitis C virus (HCV) strain JFH-1 and viral production in HuH-7 cells. In the current study, we investigated the relationships between HCV genome replication, viru...

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Detalhes bibliográficos
Main Authors: Murayama, Asako, Weng, Leiyun, Date, Tomoko, Akazawa, Daisuke, Tian, Xiao, Suzuki, Tetsuro, Kato, Takanobu, Tanaka, Yasuhito, Mizokami, Masashi, Wakita, Takaji, Toyoda, Tetsuya
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861710/
https://ncbi.nlm.nih.gov/pubmed/20442786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000885
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