Sphingomyelin Activates Hepatitis C Virus RNA Polymerase in a Genotype-Specific Manner

Hepatitis C virus (HCV) replication and infection depend on the lipid components of the cell, and replication is inhibited by inhibitors of sphingomyelin biosynthesis. We found that sphingomyelin bound to and activated genotype 1b RNA-dependent RNA polymerase (RdRp) by enhancing its template binding...

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Detalhes bibliográficos
Main Authors: Weng, Leiyun, Hirata, Yuichi, Arai, Masaaki, Kohara, Michinori, Wakita, Takaji, Watashi, Koichi, Shimotohno, Kunitada, He, Ying, Zhong, Jin, Toyoda, Tetsuya
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2977884/
https://ncbi.nlm.nih.gov/pubmed/20844041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00638-10
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