Sphingomyelin Activates Hepatitis C Virus RNA Polymerase in a Genotype-Specific Manner

Hepatitis C virus (HCV) replication and infection depend on the lipid components of the cell, and replication is inhibited by inhibitors of sphingomyelin biosynthesis. We found that sphingomyelin bound to and activated genotype 1b RNA-dependent RNA polymerase (RdRp) by enhancing its template binding...

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Bibliografski detalji
Glavni autori: Weng, Leiyun, Hirata, Yuichi, Arai, Masaaki, Kohara, Michinori, Wakita, Takaji, Watashi, Koichi, Shimotohno, Kunitada, He, Ying, Zhong, Jin, Toyoda, Tetsuya
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2010
Teme:
Virus-Cell Interactions
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2977884/
https://ncbi.nlm.nih.gov/pubmed/20844041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00638-10
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