The NS3 Helicase and NS5B-to-3′X Regions Are Important for Efficient Hepatitis C Virus Strain JFH-1 Replication in Huh7 Cells

The JFH-1 strain of hepatitis C virus (HCV) is a genotype 2a strain that can replicate autonomously in Huh7 cells. The J6 strain is also a genotype 2a strain, but its full genomic RNA does not replicate in Huh7 cells. However, chimeric J6/JFH-1 RNA that has J6 structural-protein-coding regions and J...

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Main Authors: Murayama, Asako, Date, Tomoko, Morikawa, Kenichi, Akazawa, Daisuke, Miyamoto, Michiko, Kaga, Minako, Ishii, Koji, Suzuki, Tetsuro, Kato, Takanobu, Mizokami, Masashi, Wakita, Takaji
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2007
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951293/
https://ncbi.nlm.nih.gov/pubmed/17522229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02088-06
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