Nonhepatic Cell Lines HeLa and 293 Support Efficient Replication of the Hepatitis C Virus Genotype 2a Subgenomic Replicon

The hepatitis C virus (HCV) genotype 2a subgenomic replicon can replicate in two human non-hepatocyte-derived cell lines, HeLa and 293, with in vitro-transcribed replicon RNA. Sequencing analysis revealed that mutations in HCV-derived regions were not essential for replication in these cells, as som...

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Autores principales: Kato, Takanobu, Date, Tomoko, Miyamoto, Michiko, Zhao, Zijiang, Mizokami, Masashi, Wakita, Takaji
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC538706/
https://ncbi.nlm.nih.gov/pubmed/15596851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.1.592-596.2005
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