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Suppressor of Cytokine Signaling-2 Gene Disruption Promotes Apc(Min/+) Tumorigenesis and Activator Protein-1 Activation
Epigenetic in vitro and in vivo studies suggest that suppressor of cytokine signaling-2 (SOCS2) may normally limit tumorigenesis in the intestine; however, this theory has not been directly tested. We hypothesized that SOCS2 deficiency promotes spontaneous intestinal tumorigenesis in Apc(Min/+) mice...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Society for Investigative Pathology
2010
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2861097/ https://ncbi.nlm.nih.gov/pubmed/20348236 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090684 |
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